The Secret to Living to 100? It’s Not Good Habits
Good genes matter more the older you get
Good genes matter more the older you get
If you want to live to your 100th birthday, healthy habits can only get you so far.
Research is making clearer the role that genes play in living to very old age. Habits like getting enough sleep, exercising and eating a healthy diet can help you stave off disease and live longer, yet when it comes to living beyond 90, genetics start to play a trump card, say researchers who study ageing.
“Some people have this idea: ‘If I do everything right, diet and exercise, I can live to be 150.’ And that’s really not correct,” says Robert Young, who directs a team of researchers at the nonprofit scientific organisation Gerontology Research Group.
About 25% of your ability to live to 90 is determined by genetics, says Dr. Thomas Perls, a professor of medicine at Boston University who leads the New England Centenarian Study, which has followed centenarians and their family members since 1995. By age 100, it’s roughly 50% genetic, he estimates, and by around 106, it’s 75%.
Knowing what enables some people to live very long lives has consequences for the rest of us. Ongoing research into very old age may help provide insight that could eventually be used to develop drugs or identify lifestyle changes to help people live healthier for longer, says Dr. James Kirkland, president of the American Federation for Aging Research.
Centenarians make up a growing share of the U.S. population. There are about 109,000 centenarians living in the country in 2023, according to Census Bureau projections, up from about 65,000 10 years ago, thanks in part to decades of advances in medicine and public health.
Despite a decline in life expectancy, which dropped to 76.4 in 2021, Perls estimates that roughly 20% of the population has the genetic makeup that could get them to 100 if they also make consistent healthy choices.
Not only do centenarians live longer, but data suggest they manage to avoid or delay age-related diseases like cancer, dementia and cardiovascular disease longer than the general population. Among the New England Centenarian Study participants, 15% are “escapers,” or people with no demonstrable disease at the age of 100; some 43% are “delayers,” those who didn’t develop age-related disease until age 80 or after.
Chuck Ullman, who is 97 and lives in a retirement community in Thousand Oaks, Calif., says he is free of health problems—aside from a sore right shoulder from a recent electric biking accident—and has no desire to live to a particular age. He hopes to live as long as he feels good and can do the things he loves, such as woodworking, attending political discussion groups and getting dinner with some of his many friends.
“There are 350 residents here, and I have 350 friends,” Ullman says of his community. He also spends time with Betty, his wife of 77 years. “My objective is to enjoy each and every day that comes along.”
Researchers have identified some genes and combinations of them that are associated with longevity, such as the presence of a variant of what’s known as the apolipoprotein E gene called e2, a trait thought to help protect against Alzheimer’s. They emphasise each trait is a small piece in a large, complicated puzzle, which can factor in socioeconomic status, race and ethnicity, and climate.
Living past 100 requires a combination of many genetic variants, each with a relatively modest effect, says Perls of the New England Centenarian Study.
Gene variants that offer protective qualities, such as repairing DNA damage, are especially beneficial, he says.
People who are curious about how long they might live should start by looking at their family histories. Your relatives’ lifespans are one of the strongest predictors of longevity, says Perls. Ullman, the 97-year-old, says his mother lived to 90.
If multiple members of your family have lived into very advanced age, “you’ve potentially won a much greater chance of having purchased the right lottery ticket,” says Perls.
Neurologist Dr. Claudia Kawas has been tracking the habits of the “oldest old,” those older than 90, in Southern California since 2003, as part of a study at the University of California, Irvine. She and a team of researchers have found links between longevity and even short amounts of exercise, social activities such as going to church, and modest caffeine and alcohol intake.
“Super-agers,” or people over the age of 80 whose cognitive abilities are on par with those 20 to 30 years younger, reported having more warm, trusting, high-quality relationships with other people than cognitively normal participants, investigators at Northwestern University found.
“Keeping in good relationships could be one key to healthspan,” says Amanda Cook Maher, a neuropsychologist at the University of Michigan and lead author of the study.
Your outlook also matters. Harvard researchers identified a link between optimism and longer lifespans in women across racial and ethnic groups. Among the study participants, the 25% who were the most optimistic had a greater likelihood of living beyond 90 years than the least-optimistic 25%, according to the 2022 study published in the Journal of the American Geriatrics Society.
Jeanne Case, 100, says she has taken a glass-half-full approach to life.
She plans to outlive her colon and skin cancers and keep enjoying swing music and Mexican food as long as she feels physically and mentally well.
A day in her life can include walking a mile, conversing with her writing group or noshing on fish tacos with friends. The Irvine, Calif., resident has always exercised but also enjoys indulgences like cheesecake and lemon bars.
“I try not to let stress bother me,” she says.
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The 73-year-old star of ‘Wicked: For Good’ gets cameras flashing with his kooky off-screen style. Here, he discusses his morning stretch routine, a work-in-progress sock drawer and his antagonism toward fitness rings.
From a young age, Jeff Goldblum had an eye for clothes. Growing up in Pittsburgh, he wanted glasses like John Lennon’s and turtlenecks like the Rat Pack’s.
As a member of New York’s Neighborhood Playhouse studying under the legendary Sanford Meisner, he scoured vintage shops for Russian-style overcoats and aviator hats.
After his success in blockbusters like “Jurassic Park” and “Independence Day,” he went through a Japanese-denim phase and loved what he calls “I’ve-been-working-on-the-railroad-type vests.”
“I’ve swung wildly, and I’ve had a lot of bad ideas,” Goldblum said of his style on a recent Zoom.
The 73-year-old wore a bespoke green shirt from Anto, a shirtmaker based near his Los Angeles home.
On his feet were light-green socks, and handmade shoes from Florence, where he lives part-time with his wife, Emilie Livingston, and their two sons.
This month, he reprises his role as the Wizard of Oz in “Wicked: For Good,” the second installment of the film adaptation of the musical juggernaut. He insisted he’s not contracted by Universal Studios to only wear green on the press tour.
In the last decade the world has paid more attention to the actor’s off-screen style, which has evolved since he began working with stylist Andrew Vottero around 2014.
A silver-haired fixture on best-dressed lists, Goldblum often finishes his zany outfits with chunky black specs. He has collaborated with glasses label Jacques Marie Mage and formed a close relationship with Prada , walking its runway and appearing in a 2022 brand campaign.
Here, Goldblum, who regularly performs with his jazz band the Mildred Snitzer Orchestra, talks cashmere, vegan Bolognese and handshakes.
Studying with Sandy Meisner was: a portal into my more-intense interest in clothing. Everything could be a key to finding a character, behavior and discovering who you are in the story – (for example) how the shoe felt and how it made you walk.
You don’t really see: a 1970s-style long shirt collar in stores. I had this green shirt I’m wearing made at Anto in Los Angeles. I have them in a bunch of flavors, including some with Western buttons. I’m thinking about getting one in orange.
I just read: James Kaplan’s two-part biography of Frank Sinatra, whose favorite colour was orange. I’ve always liked orange.
I like: that Marie Kondo book “Tidying Up.” In my youth, my family left me alone one day in the garage. It seemed messy to me. I started to throw everything away. I was sweating under my arms with excitement. I got a big kick out of it.
My kids: like to wear my band merchandise. They sometimes help me dress. I say, “Hey, pick out what I’m going to wear.”
I’ve had to get cozy with one or two: leather jackets for parts like Ian Malcolm in “Jurassic Park.” I have a Saint Laurent motorcycle jacket that I wore the other day that’s kind of tight. I like it a lot.
I probably wouldn’t want to wear: real fur. I’ve stopped eating animals except fish. It’s part health-wise from my nutritionist and part my own feeling about it.
My favourite meal is at: Craig’s in West Hollywood. My wife and I share a chopped salad, minus the cheese, to start. They have a spaghetti squash primavera with broccoli and a spicy tomato sauce. I get it with shrimp or vegan Bolognese.
I’ve always been hypersensitive to: certain fabrics, such as wool. I’ve recently accepted—what’s that wool called?—cashmere. I don’t like things that itch. And I don’t like tags in the back of my shirt. I use a professional seam ripper to cut out tags.
What drives me crazy are: printing machines and my phone, especially how it breaks down so often. I had to deal with that this morning.
My feet must be: comfy cozy. My wife, a ballet dancer, says we’re not really working unless our feet are bleeding. I can’t accept that. I really like these handmade shoes I had made in Florence. They’re the most comfortable ever.
Florence is: a jewel box of a city. I’ve found the people delightful and the quality of life great. There are so many artisans. My favourite hat is one I purchased at the Borsalino store. I don’t know any Italian. Just a word here or there.
I don’t want to get sick so I prefer: fist bumping to a handshake. My knuckles have hurt from a too-hard fist bump. So let’s fist bump gently. Let’s just fist touch.
I have to organise my: sock drawer. It’s in the research and development stage. I’m very into socks of one kind or another. I like to experiment with a colour, which is why I have a light green pair on now. For tight shoes, I like (thin) Pantherella socks . I like a shorter sock, too. Sometimes I make it look like it’s falling down.
For a while I had an aesthetic allergy to: cobalt blue. You’d see it on a lady’s blouse sometimes, and I would go, “That hurts! It’s too bright.” But yesterday, after going to the Dodgers game with my kids, I put on a Dodgers blue cobalt sock, and I was very happy. So I’m nothing if not changeable.
I love: pockets. I recently got a minty green chore coat by the Row that I really like. Its flap pockets are deep enough that things aren’t going to fall out. I’d never even heard the term “chore coat.” It carries my wallet, keys, maybe a Kleenex, a lozenge, a little pillbox with an aspirin and some hand sanitizer.
I never used: sunscreen. But my wife has got me using Sarah Chapman sunscreen , sometimes even tinted. I’ll use a Joanna Vargas serum of some kind. I’m not sure what it’s doing, but I put it on at night. I imitate Boris Karloff (in the “Frankenstein” films) and I make a joke with Emilie that I’m going to my laboratory to work on my new longevity theorem.
My acid-reflux man said: “Take care of your vocal cords.” So I’m off caffeine. I’ll have a Ryze mushroom coffee in the morning—a scoop with hot water and oat milk. Sometimes the kids will make me a decaf cappuccino with oat milk and a sprinkling of chocolate powder, and that is too delightful.
For many decades: I’ve been totally on the natch. I’ll have a sip of red wine if Emilie says it’s really fantastic, but I don’t want to get loopy.
I get the usual: seven or eight hours of sleep. I stopped wearing my Oura ring. I’d be in bed for 8 hours and it would go, “No, Jeff, let’s call it 5½ hours that you got.” It used to say, “You’re somewhat ready for the day,” and I’d say, “Go to H-E-Double Hockey Sticks.” I threw the darn thing away. I go with how I feel.
When I wake up: I go through the little vestige of transcendental meditation I learned decades ago. I crack my bones and do this stretching routine that ends with my taking a tennis racket and going through the motion of a backhand, forehand and serve. Then I take a Centrum for Men multivitamin, play my piano and work out in our gym.
Early on I was: a lanky guy. Then I started lifting weights. I wanted to steer some of those roles that were a little nerdy—even those scientist parts—in a cooler direction.
Am I: nerdy or cool? Well, these days, according to some circles, the two have overlapped. At this point, who knows?